Pair Name	Dihydroartemisinin, Capecitabine
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Gene Regulation	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	TCF7	hsa6932
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	GSK3B	hsa2932
	Down-regulation	Expression	MKI67	hsa4288
	Down-regulation	Expression	PECAM1	hsa5175
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	DLD-1	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0248
	HCT 15	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0292
	SW620	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0547
	CT26	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_7254
In Vivo Model	CT26 cells (8×10⁵) were injected into the tail vein of BALB/c mice to establish the lung metastasis model. HCT116 cells (2×106) were injected into the tail vein of BALB/c nude mice to establish the peritoneal metastasis model.
Result	DHA in combination with Cap could be a novel therapeutic strategy for CRC with improved efficacy and reduced side effects.